Uzbekistan host one of the largest Armenian populations in the post-Soviet space. According to official data, there are about 80,000 Armenians living there, 50,000 of whom have Uzbek citizenship. Armenians are mainly concentrated in the cities of Tashkent (50,000) and Samarqand (25,000). There are also Armenian communities in Andijan and Fergana.

After Uzbekistan's declaration of independence in 1991, the Tashkent Armenian Cultural Center and the Luys Cultural Center in Samarkand were established.

An Armenian Sunday school was opened in Tashkent in 1993. Choir, dance, drama, and art studios were also established around this time. 

On the initiative of the USSR People's Artist Tamara Khanum-Petrosian, the Armenian National Cultural Center of Uzbekistan was established in 1989. Arkady Grigoryan, who authored the book "Armenians in Central Asia" served as the center’s first president. 

In 2005, the “Art” studio was established adjacent to the center, and the "Future" charitable foundation was set up to support the construction of an Armenian house of culture, school, and church in Tashkent. In the same year, the community organization began publishing the “Apaga” newspaper, which in 2008 turned into a magazine called “Towards the Future.” There is currently an online version of the magazine, titled “Living Diaspora.”

The new office of the Armenian National Cultural Center opened in Samarqand in January 2010. There are currently two Armenian churches in Uzbekistan, St. Astvatsatsin in Samarkand, and St. Philip in Tashkent. 

Well recognized in Tashkent, are the Armenian dance groups, “Ardzagank” and “Artvin,” as well as the “Future” football team. Additionally, the “Nairi” dance ensemble is widely recognized in Samarqand.

During Tamara Khanum's life (1986), her house-museum opened in Tashkent, featuring her dance costumes, photos, unpublished memoirs. Visitors can also listen to songs by Armenian artists. The museum often serves as a gathering place for the Armenian community.