According to various sources, Armenians have settled in Brazil since the 1890s when individual Armenian families from Constantinople and the provinces of Western Armenia crossed the ocean and began to live in the eastern regions of Brazil. In the second half of the 19th century, Armenians began to move to other countries, including the Americas due to the daily persecution and massacres of Armenians in the Ottoman Empire. However, the formation of the Brazilian-Armenian community took place in 1920-1926, when large groups of Armenians mainly from Cilicia, settled in São Paulo.

The Brazilian-Armenian community grew in the 1950s and late 1960s when groups of Armenians moved from Lebanon, Syria, Turkey, Egypt, and France to Brazil. They settled in the cities of São Paulo, Rio de Janeiro, Porto Alegre, and Fortaleza. Data reports estimate the number of Armenians in Brazil at 50,000.

Armenians have notable careers in trade, financial services, science, education, medicine, culture, and politics.

In Brazil, there are Armenian Apostolic, Catholic and Evangelical churches, one school and kindergarten, as well as an Armenian Studies Chair at the University of São Paulo. In the community, there are patriotic, charitable, cultural, educational, and sports organizations/unions. There are dance groups, choirs, and broadcasted radio stations.

The Brazilian-Armenian community is governed by its own charter (ratified by the Brazilian government), where a forty member National Representative Body is elected, which in turn elects the Central Administrative Council.

In 1970, with the support of the local Armenian community and churches, a monument to the victims of the Armenian Genocide was erected. In São Paulo, there is a square, bridge, and metro station called "Armenia". An Armenian khachkar is placed in the park of the Legislative Assembly of São Paulo.

The Brazilian Senate recognized the Armenian Genocide in 2015.